Human Retinoic Acid Receptor gamma (RARG) activation kit by CRISPRa

CAT#: GA104026

RARG CRISPRa kit - CRISPR gene activation of human retinoic acid receptor gamma

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RARG
• Locus ID: 5916
• Kit Components:

  GA104026G1, Retinoic Acid Receptor gamma gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104026G2, Retinoic Acid Receptor gamma gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104026G3, Retinoic Acid Receptor gamma gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000966, NM_001042728, NM_001243730, NM_001243731, NM_001243732
• Synonyms: NR1B3; RARC
• Summary: 'This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]'