Human RPGR activation kit by CRISPRa

CAT#: GA104137

RPGR CRISPRa kit - CRISPR gene activation of human retinitis pigmentosa GTPase regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RPGR
• Locus ID: 6103
• Kit Components:

  GA104137G1, RPGR gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104137G2, RPGR gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104137G3, RPGR gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000328, NM_001023582, NM_001034853, NM_001367245, NM_001367246, NM_001367249, NM_001367250, NM_001367251, NR_159804, NR_159807, NR_159808, NM_001367247, NM_001367248, NR_159803, NR_159805, NR_159806
• Synonyms: COD1; CORDX1; CRD; orf15; PCDX; RP3; RP15; XLRP3
• Summary: 'This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined. [provided by RefSeq, Dec 2008]'