Human SCN1A activation kit by CRISPRa

CAT#: GA104290

SCN1A CRISPRa kit - CRISPR gene activation of human sodium voltage-gated channel alpha subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SCN1A
• Locus ID: 6323
• Kit Components:

  GA104290G1, SCN1A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104290G2, SCN1A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104290G3, SCN1A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001165963, NM_001165964, NM_001202435, NM_006920, NM_001353948, NM_001353949, NM_001353950, NM_001353951, NM_001353952, NM_001353954, NM_001353955, NM_001353957, NM_001353958, NM_001353960, NM_001353961, NR_148667
• Synonyms: EIEE6; FEB3; FEB3A; FHM3; GEFSP2; HBSCI; NAC1; Nav1.1; SCN1; SMEI
• Summary: 'Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. This gene encodes a sodium channel alpha subunit, which has four homologous domains, each of which contains six transmembrane regions. Allelic variants of this gene are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript. [provided by RefSeq, Oct 2015]'