Human Sterol carrier protein 2 (SCP2) activation kit by CRISPRa

CAT#: GA104307

SCP2 CRISPRa kit - CRISPR gene activation of human sterol carrier protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SCP2
• Locus ID: 6342
• Kit Components:

  GA104307G1, Sterol carrier protein 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104307G2, Sterol carrier protein 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104307G3, Sterol carrier protein 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001007098, NM_001007099, NM_001007100, NM_001007250, NM_001193599, NM_001193600, NM_001193617, NM_002979, NM_001330587
• Synonyms: NLTP; NSL-TP; SCP-2; SCP-CHI; SCP-X; SCPX
• Summary: 'This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]'