Human SDHD activation kit by CRISPRa

CAT#: GA104347

SDHD CRISPRa kit - CRISPR gene activation of human succinate dehydrogenase complex subunit D

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SDHD
• Locus ID: 6392
• Kit Components:

  GA104347G1, SDHD gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104347G2, SDHD gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104347G3, SDHD gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001276503, NM_001276504, NM_001276506, NM_003002, NR_077060
• Synonyms: CBT1; CII-4; CWS3; cybS; PGL; PGL1; QPs3; SDH4
• Summary: 'This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]'