Human SIAH2 activation kit by CRISPRa

CAT#: GA104409

SIAH2 CRISPRa kit - CRISPR gene activation of human siah E3 ubiquitin protein ligase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SIAH2
• Locus ID: 6478
• Kit Components:

  GA104409G1, SIAH2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104409G2, SIAH2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104409G3, SIAH2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005067
• Synonyms: hSiah2
• Summary: 'This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]'