Human SIM2 activation kit by CRISPRa

CAT#: GA104419

SIM2 CRISPRa kit - CRISPR gene activation of human SIM bHLH transcription factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SIM2
• Locus ID: 6493
• Kit Components:

  GA104419G1, SIM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104419G2, SIM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104419G3, SIM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005069, NM_009586
• Synonyms: bHLHe15; HMC13F06; HMC29C01; SIM
• Summary: 'This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]'