Human SLC10A1 activation kit by CRISPRa

CAT#: GA104474

SLC10A1 CRISPRa kit - CRISPR gene activation of human solute carrier family 10 member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC10A1
• Locus ID: 6554
• Kit Components:

  GA104474G1, SLC10A1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104474G2, SLC10A1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104474G3, SLC10A1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003049
• Synonyms: NTCP
• Summary: 'The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]'