Human Fascin (FSCN1) activation kit by CRISPRa

CAT#: GA104537

FSCN1 CRISPRa kit - CRISPR gene activation of human fascin actin-bundling protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FSCN1
• Locus ID: 6624
• Kit Components:

  GA104537G1, Fascin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104537G2, Fascin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104537G3, Fascin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003088
• Synonyms: FAN1; HSN; p55; SNL
• Summary: 'This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]'