Human Superoxide Dismutase 3 (SOD3) activation kit by CRISPRa

CAT#: GA104559

SOD3 CRISPRa kit - CRISPR gene activation of human superoxide dismutase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SOD3
• Locus ID: 6649
• Kit Components:

  GA104559G1, Superoxide Dismutase 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104559G2, Superoxide Dismutase 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104559G3, Superoxide Dismutase 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003102
• Synonyms: EC-SOD
• Summary: 'This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]'