Human TRIM21 activation kit by CRISPRa

CAT#: GA104633

TRIM21 CRISPRa kit - CRISPR gene activation of human tripartite motif containing 21

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRIM21
• Locus ID: 6737
• Kit Components:

  GA104633G1, TRIM21 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104633G2, TRIM21 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104633G3, TRIM21 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003141
• Synonyms: RNF81; Ro/SSA; RO52; SSA; SSA1
• Summary: 'This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]'