Human STK3 activation kit by CRISPRa

CAT#: GA104674

STK3 CRISPRa kit - CRISPR gene activation of human serine/threonine kinase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: STK3
• Locus ID: 6788
• Kit Components:

  GA104674G1, STK3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104674G2, STK3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104674G3, STK3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256312, NM_001256313, NM_006281
• Synonyms: KRS1; MST2
• Summary: 'This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]'