Human Aurora A (AURKA) activation kit by CRISPRa

CAT#: GA104676

AURKA CRISPRa kit - CRISPR gene activation of human aurora kinase A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AURKA
• Locus ID: 6790
• Kit Components:

  GA104676G1, Aurora A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104676G2, Aurora A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104676G3, Aurora A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001323303, NM_001323304, NM_001323305, NM_003158, NM_003600, NM_198433, NM_198434, NM_198435, NM_198436, NM_198437
• Synonyms: AIK; ARK1; AURA; BTAK; PPP1R47; STK6; STK7; STK15
• Summary: 'The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]'