Human TBX5 activation kit by CRISPRa

CAT#: GA104766

TBX5 CRISPRa kit - CRISPR gene activation of human T-box transcription factor 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TBX5
• Locus ID: 6910
• Kit Components:

  GA104766G1, TBX5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104766G2, TBX5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104766G3, TBX5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000192, NM_080717, NM_080718, NM_181486
• Synonyms: HOS
• Summary: 'This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]'