Human TBXAS1 activation kit by CRISPRa

CAT#: GA104771

TBXAS1 CRISPRa kit - CRISPR gene activation of human thromboxane A synthase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TBXAS1
• Locus ID: 6916
• Kit Components:

  GA104771G1, TBXAS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104771G2, TBXAS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104771G3, TBXAS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001061, NM_001130966, NM_001166253, NM_001166254, NM_001314028, NM_030984, NR_029394, NM_001366538, NR_159363, NR_159365, NM_001366537, NR_159364
• Synonyms: BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS
• Summary: 'This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]'