Human HNF1 alpha (HNF1A) activation kit by CRISPRa

CAT#: GA104780

HNF1A CRISPRa kit - CRISPR gene activation of human HNF1 homeobox A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HNF1A
• Locus ID: 6927
• Kit Components:

  GA104780G1, HNF1 alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104780G2, HNF1 alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104780G3, HNF1 alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000545, NM_001306179
• Synonyms: HNF-1A; HNF1; IDDM20; LFB1; MODY3; TCF-1; TCF1
• Summary: 'The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]'