Human LAP2 (TMPO) activation kit by CRISPRa

CAT#: GA104913

TMPO CRISPRa kit - CRISPR gene activation of human thymopoietin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TMPO
• Locus ID: 7112
• Kit Components:

  GA104913G1, LAP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104913G2, LAP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104913G3, LAP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001032283, NM_001032284, NM_001307975, NM_003276
• Synonyms: CMD1T; LAP2; LEMD4; PRO0868; TP
• Summary: 'Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]'