Human 5T4 (TPBG) activation kit by CRISPRa

CAT#: GA104946

TPBG CRISPRa kit - CRISPR gene activation of human trophoblast glycoprotein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TPBG
• Locus ID: 7162
• Kit Components:

  GA104946G1, 5T4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104946G2, 5T4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104946G3, 5T4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166392, NM_006670
• Synonyms: 5T4; 5T4AG; M6P1; WAIF1
• Summary: 'This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]'