Human TRPC6 activation kit by CRISPRa

CAT#: GA104982

TRPC6 CRISPRa kit - CRISPR gene activation of human transient receptor potential cation channel subfamily C member 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRPC6
• Locus ID: 7225
• Kit Components:

  GA104982G1, TRPC6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104982G2, TRPC6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104982G3, TRPC6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004621
• Synonyms: FSGS2; TRP6
• Summary: 'The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]'