Human Transcription termination factor 1 (TTF1) activation kit by CRISPRa

CAT#: GA105005

TTF1 CRISPRa kit - CRISPR gene activation of human transcription termination factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TTF1
• Locus ID: 7270
• Kit Components:

  GA105005G1, Transcription termination factor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105005G2, Transcription termination factor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105005G3, Transcription termination factor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001205296, NM_007344, NR_134525
• Synonyms: TTF-1; TTF-I
• Summary: 'This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]'