Human TYK2 activation kit by CRISPRa

CAT#: GA105027

TYK2 CRISPRa kit - CRISPR gene activation of human tyrosine kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TYK2
• Locus ID: 7297
• Kit Components:

  GA105027G1, TYK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105027G2, TYK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105027G3, TYK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003331
• Synonyms: IMD35; JTK1
• Summary: 'This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Jul 2020]'