Human UBF1 (UBTF) activation kit by CRISPRa

CAT#: GA105057

UBTF CRISPRa kit - CRISPR gene activation of human upstream binding transcription factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UBTF
• Locus ID: 7343
• Kit Components:

  GA105057G1, UBF1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105057G2, UBF1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105057G3, UBF1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001076683, NM_001076684, NM_014233, NR_045058
• Synonyms: NOR-90; UBF; UBF-1; UBF1; UBF2
• Summary: 'This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]'