Human LXR beta (NR1H2) activation kit by CRISPRa

CAT#: GA105083

NR1H2 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 1 group H member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NR1H2
• Locus ID: 7376
• Kit Components:

  GA105083G1, LXR beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105083G2, LXR beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105083G3, LXR beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256647, NM_007121
• Synonyms: LXR-b; LXRB; NER; NER-I; RIP15; UNR
• Summary: 'The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]'