Human VDAC3 activation kit by CRISPRa

CAT#: GA105113

VDAC3 CRISPRa kit - CRISPR gene activation of human voltage dependent anion channel 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VDAC3
• Locus ID: 7419
• Kit Components:

  GA105113G1, VDAC3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105113G2, VDAC3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105113G3, VDAC3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135694, NM_005662
• Synonyms: HD-VDAC3; VDAC-3
• Summary: 'This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]'