Human Ku80 (XRCC5) activation kit by CRISPRa

CAT#: GA105177

XRCC5 CRISPRa kit - CRISPR gene activation of human X-ray repair cross complementing 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: XRCC5
• Locus ID: 7520
• Kit Components:

  GA105177G1, Ku80 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105177G2, Ku80 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105177G3, Ku80 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021141
• Synonyms: KARP-1; KARP1; KU80; Ku86; KUB2; NFIV
• Summary: 'The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]'