Human LTBP4 activation kit by CRISPRa

CAT#: GA105563

LTBP4 CRISPRa kit - CRISPR gene activation of human latent transforming growth factor beta binding protein 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LTBP4
• Locus ID: 8425
• Kit Components:

  GA105563G1, LTBP4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105563G2, LTBP4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105563G3, LTBP4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042544, NM_001042545, NM_003573
• Synonyms: ARCL1C; LTBP-4; LTBP4L; LTBP4S
• Summary: The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]