Human Cullin 3 (CUL3) activation kit by CRISPRa

CAT#: GA105584

CUL3 CRISPRa kit - CRISPR gene activation of human cullin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CUL3
• Locus ID: 8452
• Kit Components:

  GA105584G1, CUL3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105584G2, CUL3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105584G3, CUL3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001257197, NM_001257198, NM_003590
• Synonyms: CUL-3; PHA2E
• Summary: This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]