Human SORBS2 activation kit by CRISPRa

CAT#: GA105597

SORBS2 CRISPRa kit - CRISPR gene activation of human sorbin and SH3 domain containing 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SORBS2
• Locus ID: 8470
• Kit Components:

  GA105597G1, SORBS2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105597G2, SORBS2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105597G3, SORBS2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145670, NM_001145671, NM_001145672, NM_001145673, NM_001145674, NM_001145675, NM_001270771, NM_003603, NM_021069
• Synonyms: ARGBP2; PRO0618
• Summary: Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]