Human NABC1 (BCAS1) activation kit by CRISPRa

CAT#: GA105651

BCAS1 CRISPRa kit - CRISPR gene activation of human breast carcinoma amplified sequence 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BCAS1
• Locus ID: 8537
• Kit Components:

  GA105651G1, BCAS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105651G2, BCAS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105651G3, BCAS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001316361, NM_001323347, NM_003657, NM_001366295, NM_001366296, NM_001366297, NM_001366298
• Synonyms: AIBC1; NABC1
• Summary: This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Apr 2016]