Human Apoptosis inhibitor 5 (API5) activation kit by CRISPRa
CAT#: GA105653
API5 CRISPRa kit - CRISPR gene activation of human apoptosis inhibitor 5
Find the corresponding CRISPRi Inhibitor Kit
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 3gRNAs, 1 scramble ctrl and 1 enhancer vector |
Symbol | API5 |
Locus ID | 8539 |
Kit Components | GA105653G1, API5 gRNA vector 1 in pCas-Guide-CRISPRa GA105653G2, API5 gRNA vector 2 in pCas-Guide-CRISPRa GA105653G3, API5 gRNA vector 3 in pCas-Guide-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100058 |
Disclaimer | The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001142930, NM_001142931, NM_001243747, NM_006595, NR_024625 |
Synonyms | AAC-11; AAC11 |
Summary | This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN404435 | API5 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
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Product Citations
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Yan, Zhou, Ying et al
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Smittenaar, Guitart-Masip, Lutti et al
J Neurosci (2013) 33 (46), 18087-97 DOI: 10.1523/JNEUROSCI.2167-13.2013
Haas, Mills, Yam et al
J Neurosci (2009) 29 (4), 1132-9 DOI: 10.1523/JNEUROSCI.5324-08.2009