Human PDE8B activation kit by CRISPRa

CAT#: GA105708

PDE8B CRISPRa kit - CRISPR gene activation of human phosphodiesterase 8B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDE8B
• Locus ID: 8622
• Kit Components:

  GA105708G1, PDE8B gRNA vector 1 in pCas-Guide-CRISPRa

  GA105708G2, PDE8B gRNA vector 2 in pCas-Guide-CRISPRa

  GA105708G3, PDE8B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001029851, NM_001029852, NM_001029853, NM_001029854, NM_003719, NM_001349748, NM_001349749, NM_001349750, NM_001349751, NM_001349752, NM_001349753
• Synonyms: ADSD; PPNAD3
• Summary: The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]