Human MAP2K1IP1 (LAMTOR3) activation kit by CRISPRa

CAT#: GA105732

LAMTOR3 CRISPRa kit - CRISPR gene activation of human late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LAMTOR3
• Locus ID: 8649
• Kit Components:

  GA105732G1, LAMTOR3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105732G2, LAMTOR3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105732G3, LAMTOR3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243736, NM_021970, NR_024170
• Synonyms: MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633; Ragulator3
• Summary: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]