Human TNFRSF18 activation kit by CRISPRa

CAT#: GA105831

TNFRSF18 CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 18

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFRSF18
• Locus ID: 8784
• Kit Components:

  GA105831G1, TNFRSF18 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105831G2, TNFRSF18 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105831G3, TNFRSF18 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004195, NM_148901, NM_148902
• Synonyms: AITR; CD357; GITR; GITR-D
• Summary: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]