Human TSC22D1 activation kit by CRISPRa

CAT#: GA105888

TSC22D1 CRISPRa kit - CRISPR gene activation of human TSC22 domain family member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TSC22D1
• Locus ID: 8848
• Kit Components:

  GA105888G1, TSC22D1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105888G2, TSC22D1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105888G3, TSC22D1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243797, NM_001243798, NM_001243799, NM_006022, NM_183422
• Synonyms: Ptg-2; TGFB1I4; TSC22
• Summary: This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]