Human ALDH1A2 activation kit by CRISPRa

CAT#: GA105893

ALDH1A2 CRISPRa kit - CRISPR gene activation of human aldehyde dehydrogenase 1 family member A2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ALDH1A2
• Locus ID: 8854
• Kit Components:

  GA105893G1, ALDH1A2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105893G2, ALDH1A2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105893G3, ALDH1A2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001206897, NM_003888, NM_170696, NM_170697
• Synonyms: RALDH(II); RALDH2; RALDH2-T
• Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]