Human APPBP1 (NAE1) activation kit by CRISPRa

CAT#: GA105916

NAE1 CRISPRa kit - CRISPR gene activation of human NEDD8 activating enzyme E1 subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NAE1
• Locus ID: 8883
• Kit Components:

  GA105916G1, NAE1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105916G2, NAE1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105916G3, NAE1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001018159, NM_001018160, NM_001286500, NM_003905
• Synonyms: A-116A10.1; APPBP1; HPP1; ula-1
• Summary: The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]