Human L Kynurenine Hydrolase (KYNU) activation kit by CRISPRa

CAT#: GA105961

KYNU CRISPRa kit - CRISPR gene activation of human kynureninase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KYNU
• Locus ID: 8942
• Kit Components:

  GA105961G1, KYNU gRNA vector 1 in pCas-Guide-CRISPRa

  GA105961G2, KYNU gRNA vector 2 in pCas-Guide-CRISPRa

  GA105961G3, KYNU gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001032998, NM_001199241, NM_003937
• Synonyms: KYNUU
• Summary: Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]