Human Tpit (TBX19) activation kit by CRISPRa

CAT#: GA106054

TBX19 CRISPRa kit - CRISPR gene activation of human T-box transcription factor 19

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TBX19
• Locus ID: 9095
• Kit Components:

  GA106054G1, TBX19 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106054G2, TBX19 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106054G3, TBX19 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005149
• Synonyms: dJ747L4.1; TBS19; TPIT
• Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]