Human OSMR activation kit by CRISPRa

CAT#: GA106119

OSMR CRISPRa kit - CRISPR gene activation of human oncostatin M receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OSMR
• Locus ID: 9180
• Kit Components:

  GA106119G1, OSMR gRNA vector 1 in pCas-Guide-CRISPRa

  GA106119G2, OSMR gRNA vector 2 in pCas-Guide-CRISPRa

  GA106119G3, OSMR gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001168355, NM_001323504, NM_001323505, NM_001323506, NM_001323507, NM_003999
• Synonyms: IL-31R-beta; IL-31RB; OSMRB; PLCA1
• Summary: This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]