Human Serine Palmitoyltransferase (SPTLC2) activation kit by CRISPRa

CAT#: GA106363

SPTLC2 CRISPRa kit - CRISPR gene activation of human serine palmitoyltransferase long chain base subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPTLC2
• Locus ID: 9517
• Kit Components:

  GA106363G1, SPTLC2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106363G2, SPTLC2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106363G3, SPTLC2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004863
• Synonyms: hLCB2a; HSN1C; LCB2; LCB2A; NSAN1C; SPT2
• Summary: This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]