Human RNF14 activation kit by CRISPRa

CAT#: GA106430

RNF14 CRISPRa kit - CRISPR gene activation of human ring finger protein 14

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNF14
• Locus ID: 9604
• Kit Components:

  GA106430G1, RNF14 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106430G2, RNF14 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106430G3, RNF14 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001201365, NM_004290, NM_183398, NM_183399, NM_183400, NM_183401
• Synonyms: ARA54; HFB30; HRIHFB2038; TRIAD2
• Summary: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]