Human HS2ST1 activation kit by CRISPRa

CAT#: GA106470

HS2ST1 CRISPRa kit - CRISPR gene activation of human heparan sulfate 2-O-sulfotransferase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HS2ST1
• Locus ID: 9653
• Kit Components:

  GA106470G1, HS2ST1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106470G2, HS2ST1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106470G3, HS2ST1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001134492, NM_012262
• Synonyms: dJ604K5.2
• Summary: Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]