Human DEPDC5 activation kit by CRISPRa

CAT#: GA106493

DEPDC5 CRISPRa kit - CRISPR gene activation of human DEP domain containing 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DEPDC5
• Locus ID: 9681
• Kit Components:

  GA106493G1, DEPDC5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106493G2, DEPDC5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106493G3, DEPDC5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001007188, NM_001136029, NM_001242896, NM_001242897, NM_014662, NR_110988, NR_146296, NM_001364318, NM_001364320, NM_001369902, NM_001369903, NR_157126, NR_157128, NM_001363852, NM_001363854, NM_001364319, NM_001369901, NR_157125
• Synonyms: DEP.5; FFEVF
• Summary: This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]