DEPDC5 Human Gene Knockout Kit (CRISPR)

CAT#: KN211462LP

DEPDC5 - human gene knockout kit via CRISPR, HDR mediated



HDR-mediated knockout kit validation

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USD 1,290.00

4 Weeks*

Size
    • 1 kit

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Specifications

Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Donor DNA Luciferase-Puro
Symbol DEPDC5
Locus ID 9681
Disclaimer The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001007188, NM_001136029, NM_001242896, NM_001242897, NM_014662, NR_110988, NR_146296, NM_001364318, NM_001364320, NM_001369902, NM_001369903, NR_157126, NR_157128, NM_001363852, NM_001363854, NM_001364319, NM_001369901, NR_157125
Synonyms DEP.5; FFEVF
Summary This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.