Human RAPGEF2 activation kit by CRISPRa

CAT#: GA106504

RAPGEF2 CRISPRa kit - CRISPR gene activation of human Rap guanine nucleotide exchange factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RAPGEF2
• Locus ID: 9693
• Kit Components:

  GA106504G1, RAPGEF2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106504G2, RAPGEF2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106504G3, RAPGEF2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014247, NM_001351724, NM_001351725, NM_001351726, NM_001351727, NM_001351728
• Synonyms: CNrasGEF; NRAPGEP; nRap GEP; PDZ-GEF1; PDZGEF1; RA-GEF; RA-GEF-1; Rap-GEP
• Summary: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]). [supplied by OMIM, Mar 2008]