Human KEAP1 activation kit by CRISPRa

CAT#: GA106614

KEAP1 CRISPRa kit - CRISPR gene activation of human kelch like ECH associated protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KEAP1
• Locus ID: 9817
• Kit Components:

  GA106614G1, KEAP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106614G2, KEAP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106614G3, KEAP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012289, NM_203500
• Synonyms: INrf2; KLHL19
• Summary: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]