Human SETDB1 activation kit by CRISPRa

CAT#: GA106659

SETDB1 CRISPRa kit - CRISPR gene activation of human SET domain bifurcated histone lysine methyltransferase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SETDB1
• Locus ID: 9869
• Kit Components:

  GA106659G1, SETDB1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106659G2, SETDB1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106659G3, SETDB1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145415, NM_001243491, NM_012432, NR_026977, NM_001366417, NM_001366418
• Synonyms: ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21
• Summary: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jun 2011]