Human SV2B activation kit by CRISPRa

CAT#: GA106685

SV2B CRISPRa kit - CRISPR gene activation of human synaptic vesicle glycoprotein 2B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SV2B
• Locus ID: 9899
• Kit Components:

  GA106685G1, SV2B gRNA vector 1 in pCas-Guide-CRISPRa

  GA106685G2, SV2B gRNA vector 2 in pCas-Guide-CRISPRa

  GA106685G3, SV2B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001167580, NM_001323031, NM_001323032, NM_001323033, NM_001323034, NM_001323036, NM_001323037, NM_001323038, NM_001323039, NM_001323040, NM_014848
• Synonyms: HsT19680
• Summary: This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016]