Human Josephin 1 (JOSD1) activation kit by CRISPRa

CAT#: GA106714

JOSD1 CRISPRa kit - CRISPR gene activation of human Josephin domain containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: JOSD1
• Locus ID: 9929
• Kit Components:

  GA106714G1, JOSD1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106714G2, JOSD1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106714G3, JOSD1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014876, NM_001360235, NM_001360236
• Synonyms: dJ508I15.2
• Summary: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. [UniProtKB/Swiss-Prot Function]