Human Bile Acid Receptor (NR1H4) activation kit by CRISPRa

CAT#: GA106749

NR1H4 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 1 group H member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NR1H4
• Locus ID: 9971
• Kit Components:

  GA106749G1, NR1H4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106749G2, NR1H4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106749G3, NR1H4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001206977, NM_001206978, NM_001206979, NM_001206992, NM_001206993, NM_005123, NR_135146
• Synonyms: BAR; FXR; HRR-1; HRR1; PFIC5; RIP14
• Summary: This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]